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doi:10.1006/geno.2002.6845

There is no completed human efficacy trial

Andreozzi F, Raciti GA, Nigro C, et al

Nitric oxide functions as a signaling molecule involved in vasodilation, blood flow, and tissue repair

34,35 However, the controversy surrounding the possible benefits of GIPR agonism stems from two main observations: its impaired insulinotropic effects, 36,37 and the prevention of weight gain by suppression of endogenous GIP-induced adipogenesis, 38,39 However, these seemingly discouraging observations have been questioned by the finding of the central anorexic effects of GIP, 4042 and benefits of the GLP-1R/GIPR dual agonist LY3298176 (tirzepatide) in diabetic and overweight individuals